A massive genetic study of people who lived for more than 100 years has found dozens of new clues to the biology of aging. The findings won’t be turned overnight into longevity elixirs or lifespan tests, nor do they untangle the complex interactions between biology, lifestyle and environment that ultimately determine how long — and how well — one lives. But they do offer much-needed toeholds for scientists studying the basic mechanisms of aging, which remain largely unexplained. “It shows that genetics plays an extremely important role at these extreme ages. And it begins to be a not-unsolvable puzzle,” said Boston University gerontologist Thomas Perls. “If we start looking at these genes and what they do, we better understand the biology of extreme longevity.” Published July 2 in Science, the findings come from gene tests of 801 people enrolled in the Perls-founded New England Centenarian Study, the largest study in the world of people who’ve lived past 100. People who’ve reached that mark tend to have lives that are not only exceptionally long, but unusually healthly. Unlike most people, they rarely develop diseases of aging — such as heart disease, metabolic disease, cancer and dementia — until well into their 90s. They’re also more likely to bounce back from disease, rather than entering a spiral of declining health.



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Genetic Secrets of Living to 100

A massive genetic study of people who lived for more than 100 years has found dozens of new clues to the biology of aging.

The findings won’t be turned overnight into longevity elixirs or lifespan tests, nor do they untangle the complex interactions between biology, lifestyle and environment that ultimately determine how long — and how well — one lives.

But they do offer much-needed toeholds for scientists studying the basic mechanisms of aging, which remain largely unexplained.

“It shows that genetics plays an extremely important role at these extreme ages. And it begins to be a not-unsolvable puzzle,” said Boston University gerontologist Thomas Perls. “If we start looking at these genes and what they do, we better understand the biology of extreme longevity.”

Published July 2 in Science, the findings come from gene tests of 801 people enrolled in the Perls-founded New England Centenarian Study, the largest study in the world of people who’ve lived past 100.


People who’ve reached that mark tend to have lives that are not only exceptionally long, but unusually healthly. Unlike most people, they rarely develop diseases of aging — such as heart disease, metabolic disease, cancer and dementia — until well into their 90s. They’re also more likely to bounce back from disease, rather than entering a spiral of declining health.- Read more
 
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